The latest versions of Omnisphere 3, Keyscape, Trilian and Stylus RMX are natively supported on both Apple Silicon (M1, M2, M3, etc.) and Intel Mac computers, on the following operating systems: Mac OS Tahoe, Mac OS 15 Sequoia, Mac OS 14 Sonoma, Mac OS 13 Ventura, and MacOS 12 Monterey. Beta versions of macOS are not supported. 

Regarding Omnisphere 2, which was released in 2015 and publicly available through October 2025 (prior to the release of Omnisphere3) - Omnisphere 2 is officially supported on the following operating systems: Mac OS Tahoe, Mac OS 15 Sequoia, Mac OS 14 Sonoma, Mac OS 13 Ventura, MacOS 12 Monterey, and MacOS 11 Big Sur.

If you would like to use an older version of Omnisphere, make sure it is installed on a supported operating system. We recommend upgrading to the latest version of Omnisphere here, which contains many added features and sounds in addition to compatibility with the latest operating systems and full backwards compatibility with older versions of Omnisphere.